Recent reports have demonstrated that molecularly imprinted nanogels can be utilized as enzyme mimics to catalyze representative organic reactions. The most critical aspect of this project is the synthesis of a competent transition state analog (TSA). A synthetic method has been developed to access a suitable TSA for utilization in the synthesis of a Baeyer-Villiger enzyme mimic. Progress towards this goal is evidenced by the synthesis of 2,2,6,6-tetrafluorocyclohexanone, which is the template molecule that will be used to form the requisite TSA. 2,2,6,6-tetrafluorocyclohexanone will then be treated with a functional monomer to form a robust and efficacious TSA that can be used to imprint the nanogel.

Progress towards the synthesis of a Baeyer-Villiger enzyme mimic

253rd National Meeting (2017)

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