Tuberculosis is a lung disease that is prevalent in twenty-two countries, is responsible for approximately 1.5 million deaths worldwide, and is caused by the bacterium <i>Mycobacterium tuberculosis</i>. Due to an increase in antibiotic resistant strains, understanding the function of each gene has become more important. This research focuses on a phosphatase (Rv3376) belonging to the Haloacid Dehalogenase (HAD) superfamily. Our goal is to optimize expression of and identify a substrate for this enzyme, to understand how it may contribute to the survival of the bacterium in murine macrophages.

Characterization of a haloacid dehalogenase superfamily enzyme from <i>Mycobacterium tuberculosis</i>

253rd National Meeting (2017)

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Characterization of a haloacid dehalogenase superfamily enzyme from Mycobacterium tuberculosis