The development of new and efficient methods for the formation of C—S bonds is of significant importance. Various methods have been developed that describe the formation of C—S bonds; however, most of these processes require that the substrates be activated before any reactivity is achieved. In addition, sulfur-containing heterocycles have been implicated in numerous biologically active small molecules. In an effort to develop an intramolecular C—S bond-forming process, which would allow access to highly privileged scaffolds this chemistry shall be thoroughly investigated. The project began with the development of a method that described the synthesis of O,O-diethyl S-(2-formylphenethyl) phosphorothioate, which is the common intermediate that shall be used to access a library of 2-substituted isothiochromanes. This methodology shall then be applied to the synthesis of other benzo-fused sulfur-containing heterocycles. The library of novel sulfur-containing compounds that are generated from this project shall then be probed for biological activity.

Facile synthesis of benzo-fused sulfur-containing heterocycles

253rd National Meeting (2017)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.