Proteins in the Cadherin family typically facilitate cell-cell adhesion. VE cadherin is a Cadherin protein that facilitates permeability of the vascular endothelial barrier, allowing proteins and fluids to pass through blood vessel walls. Phosphorylation (a post-translational modification) of VE-cadherin has been implicated in regulating transport across the endothelial barrier, but the mechanism by which this happens is currently unknown. Targeted, bottom-up mass spectrometry will be utilized to identify and localize sites of phosphorylation on the VE-cadherin protein under a variety of cellular conditions in order to gain a better understanding of the mechanism by which VE cadherin transport occurs.

Determination of phosphorylation site on Vascular Endothelial cadherin (VE-cadherin) using mass spectrometry

253rd National Meeting (2017)

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