Stimuli Response Polymers (SRPs) are poised to make advances in nanotherapeutic drug delivery systems. In response to chemical, physical, or biological stimuli, SRPs can control the release of a drug into a system. This project involves the synthesis of a hybrid nanomaterial consisting of three layers: a dendrimer core, a ligand linker, and a stimuli response block co-polymer. Precisely defined and organized SRPs on the dendrimer core are expected to function as a more effective nanotherapeutic for drug delivery than freely assembled block co-polymers. This research highlights the synthesis of the dendrimer core. The dendrimer core is synthesized in generational steps through alternating protection, coupling, and deprotection reactions. The 2,2-bis(hydroxymethyl) propionic acid, (bis-MPA) is protected with dimethoxy propane (DMP), and coupled with trimethylol propane (TMP), and then deprotected under acidic conditions to reveal hydroxy termini. The dendrimer core functions as an assembly site for stimuli response block co-polymers. A generation 1 dendrimer was produced and confirmed using 1H NMR and MALDI-ToF. These reactions will be repeated in order to synthesize subsequent generations of bis-MPA dendrimer, with a final goal of synthesizing a generation 3 bis-MPA dendrimer. The biocompatibility and monodispersity of bis-MPA dendrimers make them targets as potential drug delivery system platforms. To this end, the drug delivery potential of precisely defined materials made of stimuli response block co-polymers linked to the dendrimer core will be compared to that of free block co-polymers in solution.

Synthesis of generation 3-bis MPA dendrimers as a platform for novel nanotherapeutic drug delivery systems

253rd National Meeting (2017)

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