Self-spreading solid-supported lipid bilayers enable directional and bio-functionalizable coatings of solids, with experimentally convenient kinetics. Here we demonstrate that integer multiples of stacked bilayers can also self-spread. The efficiency of forming multilayers correlates to lipid charge, substrate properties, and buffer conditions. We report on the multilayer forming efficiencies of dioleoyl-tailed lipids with a broad range of positive, negative, and polar headgroup mixtures. We characterize multilayers through fluorescence microscopy and imaging ellipsometry. We are currently examining the role of the substrate on multilayer formation, as well as the possibility of manipulating multilayers with electric fields.

Forming supported lipid multilayers by self-spreading

253rd National Meeting (2017)

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