Coumarin (2H-chromone-2-one) is a plant derived phenolic natural product, possessing a wide range of pharmacological properties. The presence of the coumarin moiety is known to confer resistance in plant tissue against microbial attack and hence used as a core structure in various pesticides. Some of the commercially available coumarin based pesticides are Brodifacoum, Dicoumarol, Warfarin and Difenacoum. There is increasing resistance in plants against the marketed pesticides, therefore the development of new pesticides is the urgent need of the day for the advancement and sustainability of agriculture. In the present study a series of 4-methylcoumarin derivatives have been synthesised using a simple, convenient and green synthetic approach. All the synthesised coumarin derivatives have been fully characterized using FTIR, 1H-NMR and 13C-NMR. The antifungal activity of the synthesised coumarins was evaluated against Alternaris gaisen1. The best activity was shown by 7-hydroxy-4,5-dimethyl-2H-chromene-2-one that inhibited the fungal biomass more than 95% at 0.05 ppm concentration. The present study justifies the potential use of these newly synthesised coumarin derivatives as fungicide.

Green synthesis of coumarin derivatives in search of potent pesticides for sustainable agriculture

253rd National Meeting (2017)

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