We have developed a new class of supported-metal ion solid-phase extraction resins to target the extraction of glycosidic compounds from plant leaf tissue. We show that these supported-ion SPE resins can selectively isolate oleandrin, from Nerium oleander, in high yield and purity utilizing fewer and less hazardous solvents over published liquid-liquid extraction methods. In addition, using microwave-assisted extraction (MAE) significantly decreases the total time required to isolate the oleandrin and reduces the volume of solvents necessary by more than a factor of two. We demonstrate the practicality of scaling the isolation from the analytical scale to milligram quantities of oleandrin. The purity of the isolated oleandrin is verified with NMR spectroscopy by comparison to standard oleandrin.

Analytical- and preparative-scale isolation of oleandrin from Nerium oleander using microwave-assisted extraction coupled with purification using supported-metal ion solid phase extraction resins

253rd National Meeting (2017)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.