Tuberculosis is a worldwide epidemic that is caused by <i>Mycobacterium tuberculosis. </i>With the rise of drug resistant <i>Mycobacterium tuberculosis</i>, it has become increasingly important for a better understanding of the interaction between substrate analogs of virulance factors with membranes. A potential novel virulence factor, MenJ, has been shown to selectively reduce the second isoprene unit of the electron carrier, menaquinone (MK-9), within the electron transport chain. As MK-9 is membrane bound, it is of interest to determine the membrane interactions of the napthaquinone of MK-9. To probe the interactions of the napthaquinone of MK-9 with membranes, we explored the interactions of MK-9 analogs with only one or two isoprene units (MK-1 and MK-2, respectively) with phospholipid monolayers. Through this work, we have found differences in interactions of MK-1 and MK-2 with different lipids including dipalmitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylethanolamine (DPPE).

Interaction of Menaquinone (MK) analogs (MK-1 and MK-2) with phospholipids

253rd National Meeting (2017)

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