Polysaccharides proteins and DNA are the main polymers determining and influencing the structure and function of living biological systems. Understanding and utilizing the interaction of these three types of biopolymers with each other is prerequisite for designing new and efficient biomaterials for tissue engineering or biosensors. Polysaccharide-amino acid conjugates are materials that possess properties of the acetal and peptide world. These materials are intended to mimic nature’s proteoglycans, glycoproteins and glycosylated enzymes in form and function and are expected to carry even unprecedented properties. Development of derivatization strategies for the conjugation of polysaccharides with amino acids are the crucial step for obtaining these materials. Subsequent processing into two and three-dimensional objects (particles, coatings, foams, fibers) allows for their use in bio-medical applications. Studying interactions of living cells with the described biomaterials gives insights into the mechanisms and applicability of this relatively unexplored group of semi-synthetic bioconjugates.<br/>

Biomaterials based on polysaccharide conjugates

253rd National Meeting (2017)

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