Cocrystals, which contain two or more different compounds in a single crystal, can be used to make new materials and to change the properties of pharmaceuticals. The goal of this project was to design and synthesize a new ternary cocrystal using a carboxyphenol and two different hydrogen-bond accepting compounds bonding in the pattern shown below. After running many experiments using a range of compounds under a variety of experimental conditions, multiple cocrystals were synthesized. These cocrystals were analyzed using proton nuclear magnetic resonance to determine the identity and ratio of the components and by infrared spectroscopy to identify a change in hydrogen bonding which was indicated by a shift in NH and OH peak positions. In all, 14 new binary cocrystals and 1 new ternary cocrystal were synthesized. Then new ternary cocrystal that was synthesized contained acridine (A), 6-hydroxy- 2-naphthoic acid (B), 2-amino- 4-chloro- 6-methylpyrimidine (C).

Design and synthesis of new ternary cocrystals using carboxyphenols

253rd National Meeting (2017)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.