Sulfonamides are structural motifs commonly found in drug molecules due to their biological properties that make them of particular importance in the field of medicinal chemistry. They belong to a specific class of drugs discovered in the 1930s, known as sulfa antibiotics. It is their antibacterial properties used in the treatment of infections that facilitate their recurring appearance in a wide variety of drug molecules. Previous methods used to synthesize sulfonamides required the use of harsh reagents and reaction conditions. Recently, syntheses of sulfonamides have shifted focus to the development of greener methods that are much more cost efficient and have shorter reaction times. The intended aim of this project is to synthesize novel sulfonamides from various types of primary amines. In order to reach the anticipated outcome, an investigation of two previously published green, one-pot methods for synthesizing sulfonamides was conducted. The two methods were chosen based on their relatively mild reaction conditions and their commitment to an environmentally friendly synthetic approach. Sulfonamides synthesized from the two different green methods are characterized according to NMR spectroscopy, IR spectroscopy, and melting point.

Synthesis of sulfonamides utilizing green, one-pot methods

253rd National Meeting (2017)

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