Zwitterionic polymers (ZP) recently emerged as biomaterials with excellent bio- and haemo-compatibility. The protein adsorption on their surfaces is lower even compared to the golden standard in the field – poly(ethylene glycol). Moreover, ZP are known to swell more in salt solutions than in pure water, which is known as the antipolyelectrolyte effect. Thus, the ZP combine antifouling properties with high ability to absorb wound exudate and at the same time maintain the moisture environment of chronic wound. Nevertheless, their potential for chronic wound management is still unrevealed. In this work, two types of ZP networks were synthesized comprising in their structure zwitterionic moieties. Both ZP types are salt-sensitive. In addition, polysulfobetain (PSB) is thermoresponsive, while polycarboxybetain (PCB) is pH sensitive, allowing for modulation of their structure and functional properties by external stimuli. The PSB and PCB hydrogels were characterized in terms of their physicomechanical properties, biocompatibility and inhibitory activities towards bacterial biofilms and major enzymes causing chronicity of the wounds, such as myeloperoxidase and matrix metalloproteinases. The potential of the hydrogels for chronic wound treatment was confirmed by <i>ex-vivo</i> experiments with clinical exudates.

Zwitterionic polymers for chronic wound management

253rd National Meeting (2017)

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