In this research the main focus of the presentation is going to be the synthesis of several different isatin thiosemicarbazone derivatives and their structural determination by NMR techniques. Isatin-5-sulfonic acid-TSC was chosen because of its water soluble properties due to the sulfonic acid group, and compared to the phenyl and methyl analogs. The molecular structures of these new compounds will be determined using 1H NMR, 13C NMR, 1H-13C HSQC (Heteronuclear Single Quantum Coherence Nuclear Magnetic Resonance), and 1H-15N HSQC. These new compounds exhibit intramolecular hydrogen bonding, as can be seen by utilizing NMR spectroscopy.

Comparison of new isatin thiosemicarbazone derivatives: NMR structure determination

253rd National Meeting (2017)

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