Monodisperse nanoparticles composed of different core metals were modified with lipids as part of an ongoing project to utilize functionalized nanoparticles as drug delivery vehicles. Nanoparticles were synthesized through a reduction reaction with sodium tri-citrate and characterized optically with a UV-vis spectrophotometer as well as physically through a NanoSight LM10 HS particle sizer. The particles were then characterized again after purification of excess ligands through centrifugation. Poly(allylamine hydrochloride) was added as a stabilizing agent as well as to flip the surface charge of the particles from negative to positive. After purification, the particles were coated with lipids and spun to purify them. Characterization data suggest that the particles maintain monodispersity and are successfully coated with both poly(allylamine hydrochloride) and lipids, as evidenced by the measured changes in size and optical properties.

Synthesis and characterization of lipid-coated nanoparticles as drug delivery vehicles

253rd National Meeting (2017)

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