This study synthesizes a series of photo-reactive betaine copolymers, and investigates their performance as coatings to reduce medical device infection and other device-associated complications. Derivatives of benzophenone methacrylate (BPMA) containing either electron-withdrawing groups or electron-donating groups at different positions were synthesized. The photoactive derivatives were copolymerized with sulfobetaine methacrylate (SBMA) with different concentration. The copolymers were characterized and their photo-reactivity was evaluated with UV-Vis spectrometer as a function of UV dosage. As applied on polyurethane substrates and exposed under UV, the surfaces were evaluated by ATR-FTIR and XPS. The coating stability was evaluated by hydrolytical and oxidative aging tests. Copolymers containing BPMA derivatives with caboxy-, nitro-, and methyl groups, while all present higher photo-reactivity, exhibit different surface performance as applied on the surfaces. Betaine groups that provide a charged environment may contribute to the hydrogen abstracting of the BPMA moieties. The coated substrates were evaluated with radio-labelled protein adsorption assay. A coating formulation were developed that reduce 100% thrombus formation with a blood loop thrombus assay. Performance of biofilm resistance of the coating is also evaluated with a few clinical-related bacteria strains.

Photo-curable betaine copolymer with high resistance to thrombus and biofilm formation

253rd National Meeting (2017)

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