Modern wound dressing materials can aid the wound healing through mechanical and antimicrobial protection, by providing optimal wound healing conditions, and through active pharmacotherapy. The trends in development of such materials are nowadays directed towards the use of renewable, natural polymers, like polysaccharides (cellulose, chitosan, alginate, and their derivatives) combined with green technologies for their preparation and modification. One of the most interesting techniques for the latter is the environmentally friendly electrospinning that is simple to use, has only minor technical/chemical limitations (e.g. related to formulation properties), uses no additional hazardous organic solvents, and allows for formation of nanofibrous matrices mimicking features and morphologies of the extracellular matrix. Such materials are therefore believed to stimulate cell proliferation and encourage wound healing. Electrospun matrices have also been shown to provide a high-surface area and micro-porosity, making them ideal for loading of drugs or other biomolecules.<br/>The focus of this presentation will be on the preparation of electrospun polysaccharide based materials with incorporated active substances; (i) incorporation of different natural extracts (chamomile, rosemary, marigold, yarrow, St John's wort and purple coneflower) for the preparation of natural antimicrobial and antioxidative materials, (ii) preparation of multi-layered materials combined with local anaesthetic and non-steroid anti-inflammatory drugs for relief of wound pain, (iii) incorporation of probiotic bacterial strains from a healthy skin microbiome for prophylactic treatment of the diabetic foot.

Electrospun polysaccharide based materials as modern wound dressings

253rd National Meeting (2017)

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