Bottom-up strategies to fabricate patterned polymers in nanoscale represent an emerging field in the development of advanced nanodevices, such as biosensors, nanofluidics, and nanophotonics. However it is still highly challenging to fabricate patterned polymers by existing bottom-up approaches with low nanometer resolution.<br/>DNA is a class of biopolymers and the molecular recognition by Watson-Crick base pairing enables a rational design of DNA nano-architectures in 2D and 3D with defined size and shape, so called, “DNA origami” which present manifold opportunities for functionalization with functional materials (nanoparticles, proteins, fluorophores, and so on) at the nanoscale with the highest precision.<sup> </sup><br/>Herein, we propose a novel technique for bottom-up fabrication of nanopatterned polymer surface on DNA origami scaffold via atom transfer radical polymerization (see Figure). Control over different nanopatterns, lengths of polymers, and composition of monomers, was achieved by tuning each single polymer growing position in a few nanometer precision on DNA origami. Our approach paves the way to the bottom-up fabrication of a large variety of nanoscale-patterned polymers with high density and flexibility, and offer various opportunities, such as the chance for crosslinkers to fix the polymeric nanostructures to remain intact even after removal of DNA origami.

Programming polymer nanoarchitectures by DNA origami technology

253rd National Meeting (2017)

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