<br/>As new drugs are being discovered every day, their delivery to the body’s systems is an integral part of their effectiveness in fighting infection. Silver nanoparticles have emerged as a vehicle to enhance drug delivery, as well as an avenue to combat bacterial infection when incorporated with antibiotic. Their use in bandages has the potential to provide economic and health benefits to those suffering from wounds. In order to test the efficacy of this combination, solutions of poly-lactic acid (PLA) with silver sulfadiazine antibiotic, were made and spun using electrospinning to synthesize nanofibers. Several different concentrations were tested to find the best concentration of silver and antibiotic combination. Results will be presented on their ability to produce a clear and significant zone of inhibition when introduced to gram-positive and gram-negative bacteria. Additionally, results will be shown for PLA and silver sulfadiazine with polyethylene vinyl acetate (PEVA).

Enhancing drug delivery using antibiotic-incorporated silver nanofibers

253rd National Meeting (2017)

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