There is no doubt that optical probe methods based upon the coupling of nanometals and energy transfer have revolutionized molecular biophysics technique for sensing. As such the devlopment of energy coupling schemes to sense in-cuvette and in-vitro events have rapidly expanded, including, SERS and the manipulation of radiative and non-radiative enhancement of an appended dye at a nanometal surface. In the presentation we will discuss the continued development of surface energy transfer (SET) methods. The appllication of SET methods to biophysical problems will be explored for 3-D structre analysis by multicolor teechniques, enhancing the sensitivity of the SET technique by incorporating a magnetic component, and as a tool to map cell evolution following transfection in in-vitro experiments will be discussed. The description of SET and the development of mathematical models to treat core@shell metal structures will be discussed

Enhanced energy coupling within a nanometal plasmon field for molecular ruler and in-vitro event mapping technologies

253rd National Meeting (2017)

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