Cerium oxide nanoparticles or nanoceria have a unique structure and interesting physicochemical properties and reactivity that vary with the size, shape and surface coating. These particles have been traditionally used in catalytic applications in automotive combustion engines, and solid oxide fuel cells, and more recently have been proposed as therapeutic agents in biomedicine. This presentation will discuss properties, characterization and novel applications of nanoceria particles in the biosensing field. These materials have tunable redox activity, optical and catalytic properties and can be used to transduce and amplify signals in chemical and biological detection schemes involving biomolecules. The resulting hybrid nanostructures integrate biorecognition, signal amplification and detection capabilities and can function as all-in-one biosensing devices. Through careful engineering design it is also possible to maintain both the functional nanoscale properties and bioactivity of these materials by printing. Design and performance characteristics of several types of nanoceria-based sensing platforms for point-of-care diagnosis, food quality control and personal exposure assessment as well as implantable and wearable biosensors for detection of physiological biomarkers will be discussed, with examples of applications. These sensors have been interfaced with portable databases and user-friendly signal transduction methods, have been mass-produced by printing and have demonstrated excellent analytical performance when used in the field.

Cerium oxide nanoparticles as novel biosensing tools: Properties, sensing mechanism and applications

253rd National Meeting (2017)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.