Type 2 diabetes mellitus is a disease that causes elevated glucose levels in the blood, which can lead to various health problems if left untreated. Increasing numbers of people affected by the disease have led to research efforts to find alternative treatments in addition to insulin. Alpha-glucosidase inhibitors have shown to reduce the amount of glucose introduced into the blood from the intestines. In this project a collection of new compounds similar in structure to a known alpha-glucosidase inhibitor were synthesized and characterized. These compounds feature a glucose linked to aryl groups via a short carbon linker. Current efforts are underway to increase the yields of the synthesized products, in addition to improving their purification.  A biological assay testing the alpha-glucosidase inhibitory effects will be performed after all compounds have been synthesized, purified and confirmed via characterization. This presentation will discuss the synthesis, purification, and characterization of these compounds and the challenges that were encountered.<br/>

Exploration of α-glucosidase inhibitors via synthesis of C-linked β-D-glucose analogs

253rd National Meeting (2017)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.