The field of nanoscience is the key to develop advanced biomedical applications. In this regard, many drug delivery nanocarriers have been extensively explored. An innovative approach is the transport using polymersomes, particles which mimic the natural phospholipids based liposomes. The polymersomes are based on synthetic block-co-polymers with amphiphilic nature. The formation of the polymers into polymersome vesicles is driven by self-assembly leading to a membrane, which is stabilized by crosslinking. The vesicles possess high potential as excellent nanocarriers because of their prospective biotechnological applications as drug delivery, in vivo imaging and in cell mimicry. The incorporation of pH-responsive functionalities allows the polymersomes to open and close their membrane reversibly.<sup>1</sup> This property makes them promising carries for smaller or bigger drug molecules or enzymes. Though, for biotechnological applications systematic understanding of the encapsulation mechanism, the structural and interaction properties of the polymersome vesicles in the inner part, at the surface and in the internal part of the membrane is crucial. This study shows an extensive investigation of polymersome properties based on series of cargo molecules with different size and interaction parameters. Assymetrical flow field flow fractionation, light scattering techniques and advanced microscopy studies give an insight into the complexity of these carrier systems.<br/>

Correlation between structural properties and encapsulation efficiency in polymersomes

253rd National Meeting (2017)

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