In protein aggregation diseases such as Alzheimer’s disease, which affect numerous people and are not yet curable, the strive continues to gain better knowledge in the molecular events for the diseases. In research, development of molecular tools and usage of such can aid further insight to these events.<br/>Our functionalized thiophene oligomers have been utilized in studying protein aggregates and distinct cells. The linking of a redox-active ruthenium polypyridyl complex to the oligothiophenes is a prospect for utilization within the method electrochemiluminescence, ECL, with the conjugate operating as a complement for conventional antibodies. ECL is a very sensitive method with analytical and clinical applications, wherein electrical energy is converted into radiative energy. We are synthesizing oligothiophene ruthenium (II) trisbipyridyl conjugates through stepwise synthesis and we will evaluate their photophysical properties and capabilities as ECL-luminophores.

Synthesis of oligothiophene tris(2,2'-bipyridyl)-type ruthenium (II) conjugate as electrochemiluminescence-luminophore

253rd National Meeting (2017)

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