Efficient chromatography resins are needed in both the discovery and manufacturing phases, to ensure time savings and good process economy at small and large scales. Improvements in modern Protein A based resins meet these demands e.g. by offering higher capacities and improving the chemical stability.<br/>Optimization of the solid support and ligand may enable improved binding capacities for monoclonal antibodies (mAb’s) and hence increase productivity. This work focuses on how the design of the ligand in combination with the solid support affects the performance of the resin.The impact of the choice of the resin construction for mAb binding capacity will also be presented and discussed.

Design of ligand and solid support for high capacity protein A resin

253rd National Meeting (2017)

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