The enantiomers of a biologically active molecule can have very different effects.  For example, one enantiomer can possess the desired activity, while the other enantiomer can result in off-target activities, including potential toxicity.  The development of chiral HPLC stationary phases has allowed the resolution of enantiomers at the discovery stage, and thus regulatory agencies are discouraging the submissions of racemic mixtures.  While originally most chromatographic separations required hexanes/heptanes as the weak mobile phase component, the advent of supercritical fluid chromatography (SFC) using CO<sub>2</sub> now allows these separations to occur with a much lower environmental impact and lower energy expenditures, especially on the preparative scale. In this presentation, we will discuss the positive environmental impact of SFC systems on chiral chromatography as a green alternative for enantiomeric separations. We will also discuss techniques to make SFC  chiral chromatography even more efficient.

Evolution of chiral HPLC toward greener techniques

253rd National Meeting (2017)

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