Biocompatible and water-soluble gold nanoparticles particularly those of small size which can withstand the biological media are important in contemporary research. In order to prepare this type of robust nanoparticles the surface of the organic shell must be functionalized with charged groups that can attach to proteins and deliver drugs. This work highlights the efficiency of aryl diazonium salts to construct novel water-soluble gold-carbon nanoparticles provided a reducible counter ion for the diazonium is appropriately chosen. By selecting tetrachloroaurate(III) as anion, we demonstrate that it is simple and efficient to construct water-soluble core/shell gold-aryl nanohybrids. The newly synthesized diazonium gold(III) salts and their facile reduction to gold-carbon nanoparticles have the privileges of the anionic tetrachloroaurate(III) which is easily reduced to form the gold core passivated by the organic shell. We report the first water-soluble gold-carbon nanoparticles which are extremely stable in biological solutions such as lysozyme and bovine serum albumin proteins. In addition they are resistant to coagulation in saline solutions, cationic and anionic media.

Biocompatible and water-soluble gold-carbon nanoparticles

253rd National Meeting (2017)

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