A strategy to construct different stimuli-responsive polymers from postpolymerization modifications of a single polymer scaffold via thiol-disulfide exchange has been developed. Here, we report on a random copolymer that enables the design and syntheses of a series of dual or multi-stimuli-responsive nanoassemblies using a simple postpolymerization modification step. The reactive functional group involves a side chain monopyridyl disulfide unit, which rapidly and quantitatively reacts with various thiols under mild conditions. Independent and concurrent incorporation of physical, chemical, or biologically responsive properties have been demonstrated. We envision that this strategy may open up opportunities to simplify the synthesis of multifunctional polymers with broad implications in a variety of biological applications.

Multi-stimuli-responsive amphiphilic assemblies through simple postpolymerization modifications

253rd National Meeting (2017)

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