Iron oxide nanoparticles have attracted a great deal of scientific and technological interest due to their unique structural and chemical optical properties. As a result, MNPs are used in an array of clinical applications such as cancer therapy, gene delivery, and as contrast agents for magnetic resonance imaging (MRI). The catalytic activities of myoglobin (Mb) in presence and absence of magnetic nanoparticles were studied in terms of oxidation of o-phenylenediamine (OPD) by hydrogen peroxide (H2O2). The oxidation catalyzed by both myoglobin and myoglobin-MNPs followed the Michaelis-Menten kinetics. The presence of magnetic nanoparticles significantly affected the kinetic parameters, kcat and KM of myoglobin. The catalytic efficiency (kcat/KM) of myoglobin decreased with increasing MNPs concentrations.

Effect of polyethylene glycol-coated magnetic nanoparticles on the catalytic activity of myoglobin

253rd National Meeting (2017)

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