Nitrogen-containing heterocycles represent a privileged scaffold in drug development, with almost 60% of all currently available pharmaceuticals containing a 5- or 6-membered nitrogen heterocycle. The synthesis of these compounds has been extensively explored, but current approaches often rely on harsh reaction conditions and suffer from a lack of generality. Furthermore, the generation of these motifs is often hampered by a lack of enantioselectivity. We report the use of a novel iron-catalyzed carbonyl-olefin metathesis reaction to access highly functionalized pyrroline products from readily available chiral pool reagents, and with complete retention of stereochemistry.<br/>

Accessing chiral pyrrolines via an iron(III)-catalyzed carbonyl-olefin metathesis

253rd National Meeting (2017)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.