An effective hemostasis can stop bleeding timely and avoid wound infections, which is important for saving the wounded in an accident or surgical treatment, especially the battlefield. In this study, various shapes of chitosan based nanocomposites including chitosan-nanoTiO2 fibers (CT), chitosan-xylan-nanoTiO2 powder (CXT) and chitosan-xylan-nanoTiO2/PVA nanofibrous mats (CXT/PVA) were used for hemostasis and bacterial inhibition prepared via wet-spinning, grinding and electrospinning techniques, respectively. The results of SEM and TEM exhibited that CXT/PVA had uniform distribution and the diameters of the nanofibers were in the range of 50-150nm.In the hemostatic assessment, the commercial hemostatic sponge’s hemostatic time is 560s, and amount of bleeding is 1.695g. By contrast, CXT/PVA exhibited a hemostatic time of 353s decreased by 40.0% and an amount of bleeding of 0.415g decreased by 75.5%, while the CT showed 203s and 0.315g, the CXT manifested 110s and 0.18g. All kinds of chitosan nanocomposites had better hemostatic effects than the commercial hemostatic sponge whose main ingredient is medical gelatin as well as antibacterial activities, which may be related to the amine groups of chitosan which can interact with platelets, erythrocyte and fibrinogen to promote blood coagulation. CXT/PVA exhibited high levels of porosity, gas permeation, and a high surface-to-volume ratio, that would also promote cell respiration, skin regeneration, moisture retention, removal of exudates, and hemostasis. Such hemostatic material shows promising application in the surgical treatment and the battlefield.

Various shapes of chitosan based nanocomposites and their hemostatic ability

253rd National Meeting (2017)

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