Our group is interested in mimicking the tertiary structure of proteins, albeit in a rudimentary fashion, using single-chain nanoparticles (SCNP) containing sequence defined segments. SCNP synthesis is a simple process in principle: an organic transformation is used to effect the intramolecular cross-linking of a linear polymer chain to afford an architecturally defined nanomaterial. This presentation will discuss our recent efforts using multicomponent reactions to install peptide or depsipeptide segments in SCNPs. The segments, we’ve discovered, readily aggregate via hydrogen bonding to form aggregates or well-defined folding regimes.

Single-chain nanoparticles with sequenced defined segments via multicomponent reactions

253rd National Meeting (2017)

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