Guanidine group has a crucial role to play in medicinal chemistry. Because of the presence of basic and highly polar functional group they can make interactions with various other functional groups through strong hydrogen/ionic bonding. Potent biological properties shown by the naturally occurring polycyclic molecules made guanidine group an attractive functional group in medicinal chemistry. In our research we were successful in synthesis of cyclic guanidine through formamidine chemistry. We are currently focusing on using the same strategy to synthesize natural product analogues containing cyclic guanidine group. A computational approach will be used in synthesizing selective analogues based on analogue and target interactions. All the synthesized analogues will be tested for their biological activity <i>invitro </i>to find the lead molecule(s).<br/>

Synthesis and evaluation for biological activity of cyclic guanidine containing natural product analogues

253rd National Meeting (2017)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.