The development of an innovative and sustainable commercial manufacturing process of Zerbaxa will be presented. Zerbaxa (ceftolozane/tazobactam) is a new antibacterial drug product to treat adults with complicated intra-abdominal infections and complicated urinary tract infections. The presentation will highlight key chemistry innovations that implement a Pd coupling in the end game process and detail their impact on producing a more efficient, more productive, higher yielding, and greener manufacturing process. In addition, the presentation will highlight the positive impact of a streamlined process on reducing overall manufacturing time and energy consumption.

Development of a green and sustainable commercial manufacturing process for the antibiotic Zerbaxa™

253rd National Meeting (2017)

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