Lipoquinones play key roles in the respiratory electron transport systems (ETS) of prokaryotes and eukaryotes contributing to the separation of charge across the membrane by shuttling electrons between protein complexes, acting as electron donors and acceptors. Each of these molecules contains an isoprenyl side-chain of varying length and degree of regiospecific saturation (hydrogenation of double bonds). We have initiated a study of menaquinone-2 (MK-2) with the napthone unit attached to two isoprene units.  Specifically, we examined the structure of MK-2 in different organic solvents, and the 1D and 2D <sup>1</sup>H NMR spectra suggested that the compound was changing conformation.  We also examined the electrochemistry of MK-2 in different solvents. This compound is very insoluble in water we investigated its interaction in a reverse micelle. In these studies, we found that the MK-2 associate with the interface and that the conformation change reflect the favorable interaction with the interface.  <br/>

Charaterization of menaqinone-2

253rd National Meeting (2017)

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