Biodegradable aliphatic carbonyl polymers, such as polylactides, polylactones, and polycarbonates, have been studied for applications in a broad range of resorbable medical devices. With progress in diagnostic and therapeutic technologies for the aged society, the demand for diverse and highly developed biodegradable biomaterials has increased.<br/>We now focus on poly(trimethylene carbonate) (PTMC) analogs with ether substituents for tuning surface hydration, resulting in regulated adhesion of cells and serum proteins (Figure 1). Controlled polymerization techniques by organocatalysts are also used for the safer production of such biomedical materials and the precise formation of block/random/graft copolymers. Our recent interest is directed to amphiphilic block copolymers with a mesogen-like motif for understanding their supramolecular assembly behavior and interaction with biomolecules and cells (Figure 2).

Applications of functionalized biodegradable polymers in tissue engineering and regenerative medicine

253rd National Meeting (2017)

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