Reaction methodology for the iron(III)-catalyzed carbonyl-olefin ring-closing metathesis to form 5- and 6-membered carbocycles is described. The process relies on iron, an Earth-abundant and environmentally benign transition metal, tolerates a variety of functional groups, proceeds at ambient temperatures and displays high chemoselectivity for substituted alkenes. Studies relevant to understanding the reaction chemoselectivity, the nature of the active catalyst, and intermediates in the reaction pathway has been gained through mechanistic as well as theoretical investigation and are presented herein

Iron(III)-catalyzed carbonyl-olefin metathesis

253rd National Meeting (2017)

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