Complex inorganic active sites perform challenging catalytic transformations in biological systems, such as photosystem II and nitrogenase. The effect of cluster structure on the physical and chemical properties of these active sites is not well understood.  We have developed methodologies for the rational synthesis of tetranuclear homo- and hetero-metallic cluster models. Clusters with open coordination sites have been prepared for small molecule activation.  CH and CF oxygenation has been observed for putative terminal Fe-oxo species supported by tetranuclear clusters.  Tetranuclear clusters with bridging fluoride and oxide interstitial ligands have been synthesized.  Activation of nitric oxide by these clusters has been studied as a function of the interstitial ligand and metal oxidation state. Implications for the function of biological catalysts will be discussed.<br/>

Biologically inspired clusters: Synthetic control of structure and effects on reactivity

253rd National Meeting (2017)

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