A new frustrated Lewis pair-based strategy for fluroform activation is presented. The reactive Lewis acid-CF3- adducts thus generated are potent trifluoromethylation reagents with reactivity mimicing that of a CF3 Grignard reagent, and can be used to prepare the most commonly used reagents for nucleophilic, radical, and electrophilic trifluoromethylation using cheap feedstocks and with complete regeneration of the Lewis acid.

Nucleophilic, radical, and electrophilic trifluoromethylation reagents from fluoroform

253rd National Meeting (2017)

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