Lysyl oxidase (LOX) is an enzyme in humans that is coded by the LOX gene. The LOX enzyme plays an underlying role in the metastasis of breast cancer cells. β-aminopropionitrile (β-APN), a molecule that is naturally occurring in plants, inhibits the growth of cancer cells by inhibiting the LOX enzyme. Unfortunately, β-APN is toxic to normal cells. Thus we report the synthesis inhibitors that incorporate β-APN (examples of specific targets are highlighted in the figure below). These β-APN derivatives prepared through reductive amination of an aldehyde and β-APN. The derivatives are tested by collaborators to assess ability to decrease or stop the upregulation of the LOX expression.

Synthesis of β-APN derivatives for inhibition of the LOX enzyme

253rd National Meeting (2017)

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