The Minisci reaction has found much use in medicinal chemistry to access functionalized heteroarenes.  The literature is rich with two-component couplings of nucleophilic radicals with electrophilic heteroarenes; however, examples of three-component Minisci reactions are limited.  With an interest in accessing medicinally relevant motifs, we have developed a mild, three-component Minisci reaction with good functional group tolerance.   The process involves a radical cascade where a nitrogen-centered radical is generated and utilized to form an intermediate radical that continues the multi-component transformation.  This process can be used to construct important antimalarial scaffolds in a rapid, modular manner.<br/>

Rapid access to an antimalarial drug core via a three-component minisci reaction

253rd National Meeting (2017)

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