Understanding the interactions of small molecules at interfaces is critical for understanding uptake of metabolites and their availability at cellular uptake receptors.  In this study, glycine and the short glycine peptides diglycine, triglycine, and tetraglycine are studied with regards to their interactions at the membrane mimetic interface of reverse micelles via <sup>1</sup>H NMR and DLS measurements.  It was found that with the exception of monomeric glycine, the peptides prefer to associate themselves with the interface of the reverse micelle.  Monomeric glycine, however has been shown to locate itself with the N-terminus in the ordered interstitial water of the reverse micelle between the interface and the bulk water pool, with the C-terminus located in the bulk water pool.

Interfacial interactions of glycine and short glycine peptides in confined spaces

253rd National Meeting (2017)

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