Silver nanoparticles have been utilized as antimicrobial agents for medicinal and household purposes, and concerns remain about the safety of accumulated nanoparticles in the environment. While the toxicity of nanoparticles has recently been studied, less attention has been paid to the influence of accumulated nanosilver on cell migration. Our goal was to investigate the effect of internalized silver nanoparticles on the migratory behavior of cells found in connective tissue. Wound healing assays were employed to investigate migration of fetal lung fibroblasts in culture. All assays were performed in adherent cell culture plates supplemented with various concentrations of citrate-capped silver nanoparticles. The concentration of silver nanoparticles utilized was determined to be non-toxic as confirmed by cell viability testing. Kinetic analysis of the wound area over time indicated that migration of fibroblasts in culture is impacted by increasing concentrations of internalized nanosilver, which may also influence movement of other types of migratory cells.<br/>

Effect of silver nanoparticles on migratory properties of cultured fibroblasts

253rd National Meeting (2017)

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