Fluorine chemistry has long been in the spotlight of drug discovery since the incorporation of fluorine or fluorinated groups drastically enhance the chemical, physical, and biological properties of the non-fluorinated parent molecules. Here we present complementary methods for the preparation of Cu(CF2)nCF3 reagents from either HCF3 and their application in a cross-coupling strategy that exploits regioselective introduction of a carbon-iodine bond for the introduction of CF3 and CF2CF3 into ubiquitous electron-rich alkenes present in natural products including glycals, nucleosides and indoles.

Regioselective trifluoromethylation and pentafluoroethylation of glycals and electron-rich alkenes using Cu(CF2)nCF3 reagents

253rd National Meeting (2017)

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