Sialic acids are a family of about 50 naturally occurring derivatives and N-acetyl neuraminic acid is the most common member of the sialic acid family. The stereoselective synthesis of sialic acid containing glycoconjugates is still a synthetic challenge in the field.  As a part of a program directed toward a better understating of the effect of O-protecting groups in sialylations, we report herein the introduction of Picoloyl at C-7 and the testing of the corresponding sialyl donors in several sialylation reactions, to elucidate the hypothesis of an Hydrogen-bond-mediated aglycone delivery (HAD) mechanism.  <br/>

Effects of picoloyl at C-7 in siaylation reactions

253rd National Meeting (2017)

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