Large protecting silane protecting groups, such as tris(trimethylsiloxy)chlorosilane (TTMSS-Cl), are effective protecting groups for primary amines due to their steric bulkiness, which renders the mono-protected amine fairly unreactive. Various primary amines and silanes were synthesized and studied for stability and further functionalization.

Protection of primary amines with high molecular weight silanes

253rd National Meeting (2017)

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