Amide functionality plays a vital role in the biochemical makeup of every living organism and is also prevalent in the pharmacy industry. However, pathways to the most efficient syntheses of this functional group have been challenging as temperature control, lack of scalability, energy consumption, time efficiency, and waste generation are all problematic. Therefore, a continuous flow synthesis with a heterogeneous catalyst in a flow reactor was figured to be a necessary means to synthesize the amide product. Phenylacetonitrile and several primary amines were pumped through an HPLC pump into the reactor with water and THF in a 1:8:1:4 molar ratio, respectively. It was confirmed that monitoring the reaction with a back-pressure regulator and a higher average pressure throughout the reaction increased yields.<br/>

Benzylic amide synthesis using a heterogeneous catalyzed continuous flow reactor

253rd National Meeting (2017)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.