Aurones, a subclass of naturally occurring flavonoid compounds, have shown great biological potential. Earlier studies have shown that aurones exhibit anti-cancer activity as well as a variety of other pharmacological activities, including anti-inflammatory and antioxidant properties. More specifically, these studies indicate that aurones show potential in inhibiting cyclooxygenase-2 (COX-2) activity. COX-2 is an enzyme that plays a vital role in inflammation and its associated diseases, such as cancer. Mills, et. al. recently performed molecular docking studies of several novel aurones at the COX-2 active site. Continuing this research, a synthetic pathway for one of the most promising aurone derivatives, a novel bromo-substituted aurone, has been proposed. The final target molecule will be synthesized using this route and the novel compound will be characterized.

Progress towards the synthesis of a novel bromo substituted aurone as a promising cyclooxygenase-2 inhibitor

253rd National Meeting (2017)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.