One major limitation in studying carbohydrate-protein interactions is the low binding affinity of individual carbohydrate subunits. Molecular scaffolds that display carbohydrates in a multivalent fashion are useful for studying these processes. However, the lack of methods for the preparation of well-defined molecular scaffolds remains a major limitation. In this presentation, we describe how our research aims to overcome this limitations through the synthesis and characterization of a series of well-defined and tunable glycooligomers that can be systematically designed to probe carbohydrate-protein interactions.

Synthesis of multivalent glycooligomers for studying carbohydrate-protein binding

253rd National Meeting (2017)

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