The stability of drugs is an important yet currently under-researched aspect of analytical chemistry. The stabilities of drugs in solvents are used to prepare solutions for quantitative and qualitative work. Over the last decade, new psychoactive drugs have appeared on the drug market, many of which have not been evaluated fully. One such drug is AH-7921 whose human consumption has increased in recent years. The purpose of this research is to determine the stability of the novel opioid AH-7921 in methanol and acetonitrile at room temperature (25 °C), in the refrigerator (4<sup> </sup>°C), and in the freezer (−20<sup> </sup>°C) over a period of 90 days. Samples of AH-7921 will be prepared at 1 µg/mL in both methanol and acetonitrile and then stored as individual 100 µL aliquots for 0, 3, 7, 14, 30, and 90 days. Stability will be assessed by addition of fresh internal standard to each sample prior to analysis by gas chromatography mass spectroscopy (GC-MS). Samples will be analyzed in triplicate and compared to a calibration curve to determine the concentration of the opioid remaining in each solvent. GC-MS analysis will be carried out in full scan mode so that production of breakdown products may be monitored.

Stability of AH-7921 in polar organic solvents

253rd National Meeting (2017)

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